Scopus
YÖKSİS Eşleşti
A new definition about the relationship of intercellular fluid in the brain with the mandibular and parotid lymph nodes
Microscopy Research and Technique · Ocak 2022
YÖKSİS Kayıtları
A new definition about the relationship of intercellular fluid in the brain with the mandibular and parotid lymph nodes
Microscopy Research and Technique · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ NEJAT ÜNLÜKAL →
A new definition about the relationship of intercellular fluid in the brain with the mandibular and parotid lymph nodes
Microscopy Research and Technique · 2022 SCI-Expanded
PROFESÖR ENDER ERDOĞAN →
Makale Bilgileri
DergiMicroscopy Research and Technique
Yayın TarihiOcak 2022
Cilt / Sayfa85 · 220-232
Scopus ID2-s2.0-85112657964
Özet
This study was carried out to reveal the relationship of the brain with both the mandibular lymph node (MLN) and parotid lymph node (PLN) by the hyperspectral fluorescence imaging techniques of Qdot 800 (QD) nanoparticles using in vivo. This relationship of the brain with both lymph nodes offers the preliminary morphological definition of lymphatic drainage. QD was injected into the left parietal brain lobe of each rat at a depth of 2.50 mm. In 65% of the rats that were imaged in vivo, signals were received first from the right MLN and PLN, and then from the left MLN and PLN. In contrast, in two female rats, the first signal was received from the right PLN. There was no difference between the female and male rats overall. The most noteworthy finding of this study was that the tracer injected into the left parietal lobe reached the right mandibular and parotid lymph nodules earlier. This result indicates a different and unknown pathway in the brain that communicates with the lymph nodes. Moreover, this study shows that these lymph nodes pathways can be used in the treatment of diseases such as brain trauma, cerebral edema, and Alzheimer's disease (AD).
Yazarlar (6)
1
İsmail Hakkı Nur
ORCID: 0000-0001-7215-8112
2
Hacı Keleş
3
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
4
Merve Solmaz
5
Ender Erdoğan
6
William Pérez
Anahtar Kelimeler
brain drainage
glymphatic system
intracellular fluid
lymph nodes
Qdot 800
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Niğde Ömer Halisdemir University
Nigde Turkey
Selçuk Tip Fakültesi
Konya Turkey
Universidad de la Republica
Montevideo Uruguay
Metrikler
2
Atıf
6
Yazar
5
Anahtar Kelime