Scopus
YÖKSİS Eşleşti
Synthesis and anticancer activity of new p-tertbutylcalix[4]arenes integrated with trifluoromethyl aniline groups against several cell lines
Tetrahedron · Haziran 2022
YÖKSİS Kayıtları
Synthesis and anticancer activity of new p-tertbutylcalix[4]arenes integrated with trifluoromethyl aniline groups against several cell lines
Tetrahedron · 2022 SCI-Expanded
DOÇENT MEHMET OĞUZ →
Makale Bilgileri
DergiTetrahedron
Yayın TarihiHaziran 2022
Cilt / Sayfa116
Scopus ID2-s2.0-85130324270
Özet
A new series of p-tertbutylcalix[4]arenes integrated with isomer trifluoromethyl anilines has been designed as potential anticancer agents. The integration of trifluoromethyl anilines to p-tertbutylcalix[4]arene allows the access of C4, C5, C6, C10, C11 and C12 analogues in good yields (more than 85%). To evaluate the antiproliferative activity of the prepared derivatives, the cancer cell growth inhibition assays have been performed for three cancer cell lines (HeLa, A549, MCF-7, Hep-2) and kidney normal epithelial cells (Vero). The compounds including CF3 groups at ortho position (C4 and C10) show 25 and 12 fold higher antiproliferative activity against MCF-7 cells over Vero cells, respectively. Also, C6 and C12 show 11 and 8 fold higher antiproliferative activity against HeLa cells over Vero, respectively. These results highlight that new calixarene derivates can be worthy of further studies as potential anticancer agents.
Yazarlar (1)
1
Mehmet Oguz
Anahtar Kelimeler
Calix[4]arene
Cytotoxicity
Macrocyclic
Trifluoromethyl aniline
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
10
Atıf
1
Yazar
4
Anahtar Kelime