Scopus
YÖKSİS Eşleşti
The relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats
Journal of Trace Elements in Medicine and Biology · Eylül 2023
YÖKSİS Kayıtları
The relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats
J Trace Elem Med Biol · 2023 SCI-Expanded
PROFESÖR RASİM MOĞULKOÇ →
The Relationship Between Beta Cell Activation and SLC30A8/ZnT8 Levels of the Endocrine Pancreas and Maternal Zinc Deficiency in Rats
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY · 2023 SCI-Expanded
PROFESÖR ABDULKERİM KASIM BALTACI →
The relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats
Journal of Trace Elements in Medicine and Biology · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ NEJAT ÜNLÜKAL →
Makale Bilgileri
DergiJournal of Trace Elements in Medicine and Biology
Yayın TarihiEylül 2023
Cilt / Sayfa79
Scopus ID2-s2.0-85159801837
Özet
Objectives: Zinc, which is found in high concentrations in the β-cells of the pancreas, is also a critical component for the endocrine functions of the pancreas. SLC30A8/ZnT8 is the carrier protein responsible for the transport of zinc from the cytoplasm to the insulin granules. The aim of this study was to investigate how dietary zinc status affects pancreatic beta cell activation and ZnT8 levels in infant male rats born to zinc-deficient mothers. Methods: The study was performed on male pups born to mothers fed a zinc-deficient diet. A total of 40 male rats were divided into 4 equal groups. Group 1: In addition to maternal zinc deficiency, this group was fed a zinc-deficient diet. Group 2: In addition to maternal zinc deficiency, this group was fed a standard diet. Group 3: In addition to maternal zinc deficiency, this group was fed a standard diet and received additional zinc supplementation. Group 4: Control group. Pancreas ZnT8 levels were determined by ELISA method and insulin-positive cell ratios in β-cells by immunohistochemistry. Results: The highest pancreatic ZnT8 levels and anti-insulin positive cell ratios in the current study were obtained in Group 3 and Group 4. In our study, the lowest pancreatic ZnT8 levels were obtained in Group 1 and Group 2, and the lowest pancreatic anti-insulin positive cell ratios were obtained in Group 1. Conclusion: The results of the present study; in rats fed a zinc-deficient diet after maternal zinc deficiency has been established shows that ZnT8 levels and anti-insulin positive cell ratios in pancreatic tissue, which is significantly suppressed, reach control values with intraperitoneal zinc supplementation.
Yazarlar (6)
1
Emre Goktepe
2
Saltuk Bugra Baltaci
3
Omer Unal
4
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
5
Rasim Mogulkoc
6
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
Maternal zinc deficiency
Pancreas
Zinc
ZnT8
Kurumlar
Kirikkale Üniversitesi
Kirikkale Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
6
Yazar
4
Anahtar Kelime