Scopus
YÖKSİS Eşleşti
Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats
Biological Trace Element Research · Mayıs 2024
YÖKSİS Kayıtları
Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats
Biological Trace Element Research · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ NEJAT ÜNLÜKAL →
Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats
Biological Trace Element Research · 2024 SCI
PROFESÖR RASİM MOĞULKOÇ →
Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats
Biological trace element research · 2024 SCI-Expanded
PROFESÖR ABDULKERİM KASIM BALTACI →
Makale Bilgileri
DergiBiological Trace Element Research
Yayın TarihiMayıs 2024
Cilt / Sayfa202 · 2133-2142
Scopus ID2-s2.0-85169342032
Özet
The aim of this study was to investigate how zinc deficiency and supplementation affect liver markers including autotaxin, kallistatin, endocan, and zinc carrier proteins ZIP14 and ZnT9 in rats exposed to maternal zinc deficiency. Additionally, the study aimed to assess liver tissue damage through histological examination. A total of forty male pups were included in the research, with thirty originating from mothers who were given a zinc-deficient diet (Groups 1, 2, and 3), and the remaining ten born to mothers fed a standard diet (Group 4). Subsequently, Group 1 was subjected to a zinc-deficient diet, Group 2 received a standard diet, Group 3 received zinc supplementation, and Group 4 served as the control group without any supplementation. Upon completion of the experimental phases of the study, all animals were sacrificed under general anesthesia, and samples of liver tissue were obtained. The levels of autotaxin, kallistatin, endocan, ZIP 14, and ZnT9 in these liver tissue samples were determined using the ELISA technique. In addition, histological examination was performed to evaluate tissue damage in the liver samples. In the group experiencing zinc deficiency, both endocan and autotaxin levels increased compared to the control group. With zinc supplementation, the levels of endocan and autotaxin returned to the values observed in the control group. Similarly, the suppressed levels of kallistatin, ZIP14, and ZnT9 observed in the zinc deficiency group were reversed with zinc supplementation. Likewise, the reduced levels of kallistatin, ZIP14, and ZnT9 seen in the zinc deficiency group were rectified with zinc supplementation. Moreover, the application of zinc partially ameliorated the heightened liver tissue damage triggered by zinc deficiency. This study is the pioneering one to demonstrate that liver tissue dysfunction induced by a marginal zinc-deficient diet in rats with marginal maternal zinc deficiency can be alleviated through zinc supplementation.
Yazarlar (7)
1
Meltem Gumus
2
Elif Gulbahce-Mutlu
3
Omer Unal
4
Saltuk Bugra Baltaci
5
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
6
Rasim Mogulkoc
7
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
Liver markers
Maternal zinc deficiency
Zinc
ZIP14
ZnT9
Kurumlar
İstanbul Medipol Üniversitesi
Istanbul Turkey
Karatay Üniversitesi
Konya Turkey
Kirikkale Üniversitesi
Kirikkale Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime