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The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

BMC Anesthesiology · Aralık 2021

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The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study
BMC ANESTHESIOLOGY · 2021 SCI-Expanded
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Makale Bilgileri

DergiBMC Anesthesiology
Yayın TarihiAralık 2021
Cilt / Sayfa21
Erişim🔓 Açık Erişim
Özet Background: It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. Methods: Posthoc retrospective propensity score–weighted cohort analysis of patients undergoing open or closed abdominal surgery in the ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events. Results: The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P < 0.001 versus 1.05 [95%CI 1.05 to 1.05], P < 0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P < 0.001). The association of ΔPTW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12– to 1.14], P < 0.001 versus 1.07 [95%CI 1.05 to 1.10], P < 0.001; risk difference 0.05 [95%CI 0.030.07], P < 0.001). Conclusions: ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery. Trial registration: LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223).

Yazarlar (100)

1
Guido Mazzinari
2
Ary Serpa Neto
3
Sabrine N. Hemmes
4
Goran Hedenstierna
5
Samir Jaber
6
Michael Hiesmayr
7
Markus W. Hollmann
8
Gary H. Mills
9
Marcos F. Vidal Melo
10
Rupert M. Pearse
11
Christian Putensen
12
Werner Schmid
13
Paolo Severgnini
14
Hermann Wrigge
15
Oscar Diaz Cambronero
16
Lorenzo Ball
17
Marcelo Gama de Abreu
18
Paolo Pelosi
19
Marcus J. Schultz
20
Wolfgang Kroell
21
Helfried Metzler
22
Gerd Struber
23
Thomas Wegscheider
24
Hans Gombotz
25
Bernhard Urbanek
26
David Kahn
27
Mona Momeni
28
Audrey Pospiech
29
Fernande Lois
30
Patrice Forget
31
Irina Grosu
32
Jan Poelaert
33
Veerle van Mossevelde
34
Marie Claire van Malderen
35
Dimitri Dylst
36
Jeroen van Melkebeek
37
Maud Beran
38
Stefan De Hert
39
Luc De Baerdemaeker
40
Bjorn Heyse
41
Jurgen Van Limmen
42
Piet Wyffels
43
Tom Jacobs
44
Nathalie Roels
45
Ann De Bruyne
46
Stijn van de Velde
47
Brigitte Leva
48
Sandrine Damster
49
Benoit Plichon
50
Marina Juros-Zovko
51
Dejana Djonovic-Omanovic
52
Selma Pernar
53
Josip Zunic
54
Petar Miskovic
55
Antonio Zilic
56
Slavica Kvolik
57
Dubravka Ivic
58
Darija Azenic-Venzera
59
Sonja Skiljic
60
Hrvoje Vinkovic
61
Ivana Oputric
62
Kazimir Juricic
63
Vedran Frkovic
64
Jasminka Kopic
65
Ivan Mirkovic
66
Nenad Karanovic
67
Mladen Carev
68
Natasa Dropulic
69
Jadranka Pavicic Saric
70
Gorjana Erceg
71
Matea Bogdanovic Dvorscak
72
Branka Mazul-Sunko
73
Anna Marija Pavicic
74
Tanja Goranovic
75
Branka Maldini
76
Tomislav Radocaj
77
Zeljka Gavranovic
78
Inga Mladic-Batinica
79
Mirna Sehovic
80
Petr Stourac
81
Hana Harazim
82
Olga Smekalova
83
Martina Kosinova
84
Tomas Kolacek
85
Kamil Hudacek
86
Michal Drab
87
Jan Brujevic
88
Katerina Vitkova
89
Katerina Jirmanova
90
Ivana Volfova
91
Paula Dzurnakova
92
Katarina Liskova
93
Radovan Dudas
94
Radek Filipsky
95
Samir el Kafrawy
96
Hisham Hosny Abdelwahab
97
Tarek Metwally
98
Ahmed Abdel-Razek
99
Ahmed Mostafa El-Shaarawy
100
Wael Fathy Hasan

Anahtar Kelimeler

Driving pressure Laparoscopic surgery Laparoscopy PEEP Perioperative ventilation Pneumoperitoneum Protective ventilation Respiratory mechanics

Kurumlar

Amsterdam UMC - University of Amsterdam
Amsterdam Netherlands
BG-Kliniken Bergmannstrost Halle
Halle Germany
Hospital Israelita Albert Einstein
Sao Paulo Brazil
Hospital Universitari i Politècnic La Fe
Valencia Spain
IRCCS San Martino Polyclinic Hospital
Genoa Italy
Mahidol University
Nakhon Pathom Thailand
Massachusetts General Hospital
Boston United States
Medizinische Universität Wien
Vienna Austria
Nuffield Department of Medicine
Oxford United Kingdom
Physiologie et Médecine Expérimentale du Cœur et des Muscles
Montpellier France
Queen Mary University of London
London United Kingdom
Technische Universität Dresden
Dresden Germany
The University of Sheffield
Sheffield United Kingdom
Universidade de São Paulo
Sao Paulo Brazil
Università degli Studi dell'Insubria
Varese Italy
Università degli Studi di Genova
Genoa Italy
Universitätsklinikum Bonn
Bonn Germany
Uppsala Universitet
Uppsala Sweden

Metrikler

18
Atıf
100
Yazar
8
Anahtar Kelime

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