Aim: This study aims to present the details of the program evaluating the effects of the Family-Centered Empowerment Model (FCEM) provided to individuals with Total Knee Arthroplasty (TKA) and their caregivers, on individuals' physically functioning and self-efficacy level, as well as the impact on caregivers' caregiving burden, caregiving competence, and coping skills with stress. Methods: This study is designed as randomized controlled experimental research. A total of 62 patients, including both an intervention group and a control group, will be included in the study. Data will be collected between December 2023 and August 2024 using the Participant identification form, Barthel Index of Activities of Daily Living, General Self-Efficacy Scale, Zarit Caregiving Burden Scale, Caregiving Competence Scale, and Coping with Stress Scale. Patients in the intervention group will receive counseling eight times over a five-week period, along with a structured booklet based on the FCEM. Patients in the control group will receive standard care, and in the final follow-up (after the 30th day post-surgery), they will be provided with the section of the booklet detailing the actions to be taken after the 30th day post-surgery. Results: In the statistical analysis of the data obtained from the research, descriptive statistics including frequency, percentage, mean, and standard deviation will be used. The chi-square test will be employed to compare the similarity/homogeneity of the groups in terms of their descriptive characteristics. The results will be evaluated at a significance level of p<0.05. Conclusions: Our study protocol will guide subsequent research by providing details of the FCEM program. Clinical Trial Number: NCT06402539