Aim: This study aims to evaluate the attitudes of cancer patients receiving Radiotherapy (RT) toward Traditional and Complementary Medicine (TCM), their health perceptions, the TCM methods they employ, and the connections between these factors. Methods: This descriptive, cross-sectional, and correlational study was conducted with 82 patients receiving treatment at the Radiation Oncology Clinic of Selçuk University Faculty of Medicine Hospital. Data were collected using a demographic information form, the Attitudes Toward Traditional and Complementary Medicine Scale (CACMAS), and the Perception of Health Scale (PHS). Results: A total of 52.4% of participants reported using TCM methods, with the most commonly used methods being religious practices (87.8%), manipulative approaches (massage and reflexology; 46.4%), phytotherapy (31.7%), meditation (12.2%), hypnosis (4.9%), guided imagery (2.4%), and energy-based approaches (Reiki, bioenergy, and healing energy; 1.2%). Among the participants, 26.8% obtained information from family, 14.7% from TV and social media, 12.2% from healthcare professionals, and 46.3% reported not knowing TCM. The mean CACMAS score was 97.21±30.74, and the mean PHS score was 43.48±9.01. Participants who perceived their economic status as poor had significantly higher CACMAS scores (p<0.05). Although no direct strong correlation was found between the CACMAS and PHS scores, strong positive correlations were observed between the ‘Cognitive Perspective on Complementary Medicine’ subscale and moderate positive correlations with the ‘Dissatisfaction with Modern Medicine’ and ‘Holistic Perspective on Health’ subscales. Conclusions: This study demonstrates that the sociodemographic characteristics, disease stages, and economic conditions of cancer patients undergoing RT may influence their use of TCM methods and health perceptions. Among participants, the most frequently preferred methods were religious practices, manipulative approaches, and phytotherapy, with most individuals utilizing these methods based on information obtained from social media, family, and their social circles.