In this study, we aimed to determine the relationship between women’s depression, stress, anxiety, and personal traits with their sexual function levels. We conducted cross-sectional study, among 215 women with sexually active women. We collected the research data by utilizing “Introductory Information Form”, “Depression, Anxiety, Stress Scale (DASS)”, “Female Sexual Function Index (FSFI)” and “International Personality Inventory Short Form (IPISV)”. Among the participants, 63.7% exhibited adequate levels of sexual function, and 87.9% reported satisfaction with their sexual life. We found a weak negative correlation between total FSFI scores and some sub-dimensions of the IPISV, and the DASS. Higher levels of psychological distress and marked by emotional instability, hostility, undirectedness, and closed to experience, were associated with reduced levels of sexual function. It appears that psychological and personality factors may be relevant in understanding variations in sexual function, indicating the potential value of targeted interventions in improving sexual function.