This research was conducted to examine the effect of working in Covid clinics on anxiety-depression and family-work conflict of healthcare professionals. In a study conducted with 103 health personnel, a positive and significant relationship was found between work-family conflict scale scores and depression and anxiety scale scores (1* = 481, p <.01, 1 = 483, p <.01, respectively). As a result, employees in the Covid-19 clinic are faced with problems such as fear of transmitting the infection to their families, difficulty in carrying the burden of their children, increased levels of anxiety and depression, and social and family life being affected.