Objective: This study aimed to evaluate the impact of a computer-assisted rehabilitation program on self-management, cognitive function, and quality of life in people with epilepsy (PwE). Methods: A randomized controlled trial was conducted with 44 PwE (22 intervention, 22 control) at a university hospital's neurology clinic. The intervention group received 12 sessions of the RehaCom program (45 min/session, twice a week for six weeks). Data were collected using the “Quality of Life in Epilepsy Inventory (QOLIE)”, “Epilepsy Self-Management Scale (ESMS)”, and “Moxo test” before and after the intervention. Results: The intervention group showed significant improvements in attention and timing dimensions of the MOXO test and reductions in hyperactivity symptoms compared to the control group (p < 0.05). ESMS scores, including overall self-management, information management, lifestyle management, and safety management sub-dimensions, significantly increased. Similarly, QOLIE scores, particularly in cognitive functioning, emotional well-being, and energy/fatigue, improved, while seizure worry scores decreased (p < 0.001). Significance: The computer-assisted rehabilitation program enhanced self-management, quality of life, attention, and responsiveness while reducing impulsivity and hyperactivity symptoms in PwE.