A comprehensive ethnobotanical study was carried out in the province of Kırsehir, in the Central Anatolia region. The result of that study is this publication containing information about the main traditional folk medicine, wild food plants, and other plant uses in the area. Our goal was to collect, identify, and provide information about plants traditionally used by the local population. This inquiry focused on the plant specimens obtained during field work. Data were gathered through open and semi-structured interviews conducted with local individuals, and use report (UR) values were computed. A total of 79 taxa of plants used in folk medicine, belonging to 33 families, were identified in this study. Of these, 67 taxa were wild and 12 were cultivated. The most common families were Asteraceae, Lamiaceae, and Rosaceae. Based on the results of this study, 77 taxa with ethnobotanical uses were recorded. The plants were used as folk medicine (45 taxa), as food (46 taxa), and for other purposes (34 taxa). This study determined that plants are still traditionally used in the region.