Background: Self-management practices can contribute to the lives of patients with multiple sclerosis. The aim of this study is to improve patients’ self-management abilities through the multidisciplinary developed module. Methods: This prospective, randomized controlled trial was conducted between January-2020 and November-2021 at a university hospital, Ankara, Turkiye. The Self-Management Module was implemented by a clinical pharmacist with the aim of enhancing self-management capabilities through educational approach, with focus on medication adherence, management of drug-related problems, follow-ups, and self-directed activities. The intervention group completed the self-management module, while the control group received usual outpatient care. To evaluate the impact of the module, the Multiple Sclerosis Self-Management Revised scale was administered to the patients. The interviews were conducted at 4-month intervals. Results: Study (n=102) and control group (n=98) patients were followed-up for 8 months and the median duration of intervention was 11 minutes. The mean (±SD) self-management scores of the study group increased from 68.9 (±9.3) to 79.0 (±9.4) at the end of the interviews, and this increase was found to be significant compared to the control group (p<0.001). The self-management module has been shown to improve self-management, medication adherence, perception of care and patient engagement in treatment (p<0.001). Conclusions: This single-centre randomized controlled trial suggests that a pharmacist-implemented self-management module increased patient engagement and medication adherence. The self-management interventions could be tailored to groups that tend to have lower self-management abilities, such as older individuals, those who have lower educational attainment, health engagement or medication adherence.