Although abnormal 68Ga-PSMA uptake in the prostate and its metastases can be seen in a variety of diseases, it is rare to see in the testis. In these 2 cases, 68Ga-PSMA PET/CT revealed unilateral 68Ga-PSMA uptake in the testis of 2 patients. One of these patients was diagnosed with testis metastases from prostate cancer after an orchiectomy. The other patient was diagnosed with an orchitis. 68Ga-PSMA uptake should be considered as an infection, as well as a malignancy in the initial differential diagnosis.