Background: The aim of this study was to evaluate the effect of different primers and universal adhesive used after sandblasting with aluminum oxide particles on the shear bond strength between zirconia and self-adhesive resin cement after thermal aging. Material and Methods: Twenty rectangular samples were prepared from CAD/CAM zirconia blocks with dimensions of 2 mm x 11 mm x 11 mm. Surface roughening of 50 µm Al2O3 particles was applied to the surface of all samples. Prepared samples were divided into 4 subgroups according to different primer and adhesive applications (n=5). Control: No primer or universal adhesive was applied. Kerr Silane Primer (Negative Control): Ceramic primer without MDP content was applied. Ceramica-S and Nova Compo-B Plus: Ceramica-S primer and Nova Compo-B Plus universal adhesive were mixed and applied. Clearfil Ceramic Primer Plus: Clearfil Ceramic Primer Plus has been applied. Following the surface treatments, the self-adhesive resin cement was polymerized on the ceramic surfaces. Then, the samples were subjected to 5000 cycles of thermal cycling. Shear bond strength test was applied to the samples in a universal testing device. One-Way Analysis of Variance was used to compare the Fmax (N) and Mpa values according to the surface treatments. Results: According to the use of different primers and adhesives, the mean Fmax (N) values showed a statistically significant difference (p<0,001). The value obtained with Ceramica S and Nova Compo-B Plus differed from all other primer groups and was higher (p<0,001). The value obtained with Clearfil Ceramic Primer Plus also differed from the other groups (p<0,001). The Fmax (N) values obtained in the control group and Kerr Silane Primer groups were similar (p<0,001). Conclusions: Within the current limitations, it can be concluded that the application of self-adhesive resin cement without any primer or a primer without MDP is not sufficient to improve the bond strength to the zirconia ceramic surface. Primers or adhesives containing MDP and applied after sandblasting appear to be an ideal option for bonding to zirconia.