Brucellosis is a common zoonosis in our country. It can involve every system and lead to different clinical pictures. Nervous system involvement occurs in 3-10% of brucellosis patients. Headache is a warning sign for neurobrucellosis. A 15-year-old male patient presented with fever, joint pain, headache and vomiting lasting for about five days. His physical examination was unremarkable except for an increase in the left knee joint circumference. A positive 1/1280 titer was observed in the Brucella Wright agglutination test of the patient whose C-reactive protein (CRP) elevation and Rose Bengal test were positive. Lymphocytic pleocytosis, high protein and low glucose were detected in cerebrospinal fluid (CSF). Brucella CSF PCR test and CSF agglutination test were negative. Brucella spp. grew in CSF culture. The patient’s complaints regressed rapidly with doxycycline, rifampicin and cefotaxime treatment, and the patient was discharged to complete the doxycycline and rifampicin treatment in 12 weeks.