This study was designed to determine the effects of curcumin on some acute phase proteins in rats treated with aflatoxin B1. In this study, healthy 38 male Wistar Albino rats were used. The animals in control group were given food and distilled water. The animals in DMSO group were orally given 1 ml 10% DMSO daily for 60 days, animals in Cur group was orally given 300mg/kg curcumin dissolved in 10% DMSO daily for 60 days. Animals in AFB1 group were orally given 250µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days. Animals in AFB1+Cur group was orally given 250µg/kg aflatoxin B1 dissolved in 10% DMSO and 300mg/kg curcumin dissolved in 10% DMSO daily for 60 days. In blood samples taken from all animals, fibrinogen, prothrombin, albumin and CRP levels were determined. In this study, fibrinogen, prothrombin and CRP levels with AFB1 group were found to be significantly higher than the control group (p<0.05). In the AFB1+Cur group, fibrinogen and CRP levels were lower than in the aflatoxin group (p<0.05). In the study, it was observed that albumin level in rats in AFB1 group significantly decreased compared to the control group (p<0.05) and this difference was found to be eliminated depend on the application of curcumin together with aflatoxin B1 (p<0.05). In conclusion, our findings regarding the ameliorating effects of curcumin on acute phase protein abnormalities caused by aflatoxicosis will contribute to future research.