Background/aim: Texture analysis (TA) provides additional tissue heterogeneity data that may assist in differentiating peripheral zone (PZ) lesions in multiparametric magnetic resonance imaging (mpMRI). This study investigates the role of magnetic resonance imaging texture analysis (MRTA) in detecting clinically significant prostate cancer (csPCa) in the PZ. Materials and methods: This retrospective study included 80 consecutive patients who had an mpMRI and a prostate biopsy for sus-pected prostate cancer. Two radiologists in consensus interpreted mpMRI and performed texture analysis based on their histopathology. The first-, second-, and higher-order texture parameters were extracted from mpMRI and were compared between groups. Univariate and multivariate logistic regression analyses were performed using the texture parameters to determine the independent predictors of csPCa. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic performance of the texture parameters. Results: In the periferal zone, 39 men had csPCa, while 41 had benign lesions or clinically insignificant prostate cancer (cisPCa). The majority of texture parameters showed statistically significant differences between the groups. Univariate ROC analysis showed that the ADC mean and ADC median were the best variables in differentiating csPCa (p < 0.001). The first-order logistic regression model (mean + entropy) based on the ADC maps had a higher AUC value (0.996; 95% CI: 0.989–1) than other texture-based logistic regression models (p < 0.001). Conclusion: MRTA is useful in differentiating csPCa from other lesions in the PZ. Consequently, the first-order multivariate regression model based on ADC maps had the highest diagnostic performance in differentiating csPCa.