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SCI-Expanded JCR Q3 Özgün Makale Scopus
Comparison of cases with and without acute liver injury in pregnant women with SARS-CoV-2 infection; obstetric and neonatal outcomes
Pakistan Journal of Medical Sciences 2024 Cilt 40 Sayı 3
Scopus Eşleşmesi Bulundu
40
Cilt
277-283
Sayfa
🔓
Açık Erişim
Scopus Yazarları: Nur Gozde Kulhan, Fazıl Avcı, Gökçen Örgül, Mehmet Kulhan
Özet
Background and objective: The effect of SARS-CoV-2 infection on the liver during pregnancy and the impact of SARS-COV-2-related liver injury during pregnancy on obstetric and neonatal outcomes are not yet clear. The aim of this study was to determine the clinical features of pregnant women at risk of liver injury and to investigate the effect of liver dysfunction on obstetric and perinatal outcomes. Methodology: Pregnant women who were followed up and treated at Selcuk University Medical Faculty Hospital and diagnosed with COVID-19 were determined retrospectively. All pregnant women whose PCR test results were positive between March 1, 2020 and July 31, 2022 were included. A total of 96 PCR positive pregnant women were included in the study. The patients were divided into two groups as those with and without liver damage. Both groups were compared in terms of obstetric and neonatal outcomes. Results: While liver damage findings were observed in 34.4% of the 96 pregnant included in the study; No liver damage was observed in 65.6% of the patients. White blood cell, neutrophil, ferritin, D-dimer, troponin, C-reactive protein, systemic immune-inflammation index, interleukin-6, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase levels were higher in patients with liver injury compared to pregnant women without liver injury. Prematurity, premature rupture of membranes, preterm premature rupture of membranes, preeclampsia and fetal death were observed relatively more in the patient group with liver injury, there was no statistical significiant difference between the groups in terms of these complications. Unfortunately, maternal death occurred in four mothers with liver injury and in one patient without liver injury. Birthweight, APGAR scores and obstetric complication rates were similar between two groups. Conclusion: Our study showed that pregnant patients with liver damage had worse inflammatory response than those without liver damage. Women with elevated liver enzymes tend to have severe disease, but obstetric and perinatal outcomes were similar between groups with and without liver damage.
Anahtar Kelimeler (Scopus)
COVID-19 Liver damage Pregnancy SARS-CoV-2

Anahtar Kelimeler

COVID-19 Liver damage Pregnancy SARS-CoV-2

Makale Bilgileri

Dergi Pakistan Journal of Medical Sciences
ISSN 1682-024X
Yıl 2024 / 1. ay
Cilt / Sayı 40 / 3
Makale Türü Özgün Makale
Hakemlik Hakemli
Endeks SCI-Expanded
JCR Quartile Q3
TEŞV Puanı 405,00
Yayın Dili Türkçe
Kapsam Uluslararası
Toplam Yazar 4 kişi
Erişim Türü Basılı+Elektronik
Erişim Linki Makaleye Git
Alan Sağlık Bilimleri Temel Alanı Perinatoloji (Kadın Hastalıkları ve Doğum)

YÖKSİS Yazar Kaydı

Yazar Adı KULHAN NUR GÖZDE, ÖRGÜL GÖKÇEN, AVCI FAZIL, KULHAN MEHMET
YÖKSİS ID 7530561

Metrikler

JCR Quartile Q3
TEŞV Puanı 405,00
Yazar Sayısı 4