It is difficult to reach the water needed in agriculture. For this reason, insufficient irrigation causes yield and quality losses in plants. The aim of this study was to determine some quality parameters of both flesh of melon and melon seed irrigated with different irrigation regimes. Melon cultivar (Cucumis melo L.) was irrigated by the drip method from transplantation to the beginning of vegetative development, flowering-fruit binding, and fruit development-ripening. In this context, 8 irrigation groups were formed. Sugars, total phenolic compounds, titratable acidity, antioxidant activity and color analyzes were performed on flesh of melons. Oil content and fatty acid composition of melon seeds were also determined. The titratable acidity of samples varied from 0.098 to 0.159%. Irrigation regime had a significant effect on sucrose and total sugar content. Total phenolic compounds and antioxidant activities of samples were ranged from 80.6 to 244.8 (mg GAE/kg) and 0.17 to 0.38 (mmol TE/kg), respectively. The groups of non-irrigated and irrigated at vegetative-fruit development-ripening periods had the highest amount of total phenolic compounds and antioxidant activities. Among the color parameters, there were significant differences only in a* and h values. Although palmitic acid and oil content of seeds were not different, linoleic, oleic, and stearic acids were affected significantly by irrigation regime. As a result, in terms of sugar content, amount of phenolic compound and antioxidant activity, irrigation during VF period can be suggested for cultivation of melons in arid and semi-arid regions.