Scopus Eşleşmesi Bulundu
1963
Atıf
370
Cilt
🔓
Açık Erişim
Scopus Yazarları: Paul Bastard, Qian Zhang, H. Heinrich Hoffmann, Karim Dorgham, Jérémie Rosain, Elana Shaw, Emilie Catherinot, Jérémie Le Pen, Vito Lampasona, Kaya Bilguvar, Darragh Duffy, Diederik van de Beek, Donald C. Vinh, Michel C. Nussenzweig, Carlos Rodriguez-Gallego, Guillaume Vogt, Andrea Biondi, Laura Rachele Bettini, Frédéric Rieux-Laucat, Mathilde Valeria Ursini, Alessandra Sottini, Simone Paghera, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Shen Ying Zhang, Vivien Béziat, Pärt Peterson, Lucy Bizien, Kerry Dobbs, Adriana Almeida de Jesus, Gaspard Kerner, Yoann Seeleuthner, Alexandre Bolze, Ottavia M. Delmonte, Jérome Hadjadj, Benjamin Terrier, Stuart G. Tangye, Stéphanie Boisson-Dupuis, Paolo Bonfanti, Xavier Duval, Kai Kisand, Michail S. Lionakis, Guy Gorochov, Charles M. Rice, Luigi Notarangelo, Helen C. Su, Andrés Augusto Arias, Lindsey B. Rosen, Eleftherios Michailidis, Yu Zhang, Quentin Philippot, Benedetta Bigio, Michael S. Abers, Giorgio Casari, Fabio Ciceri, Richard P. Lifton, Marc Vasse, David M. Smadja, Mélanie Migaud, Filomeen Haerynck, Javier Martinez-Picado, Trine H. Mogensen, Andrew J. Oler, Jingwen Gu, Peter D. Burbelo, Jeffrey I. Cohen, Mariella DÁngio, Patrick Rossignol, Julien Mayaux, Eystein Husebye, Francesca Fusco, Luisa Imberti, Eugenia Quiros-Roldan, Camillo Rossi, Jade Ghosn, John S. Tsang, Raphaela Goldbach-Mansky, Anne Puel, Laurent Abel, Jean Laurent Casanova, Jeremy Manry, Liis Haljasmägi, Lazaro Lorenzo, Sophie Trouillet-Assant, Alexandre Belot, Anne Kallaste, Yacine Tandjaoui-Lambiotte, Rui Yang, András N. Spaan, Alessandro Aiuti, Lorenzo Piemonti, Lluis Quintana-Murci, Lucie Roussel, David Dalmau, Petter Brodin, Riccardo Castagnoli, Steven M. Holland, Emmanuelle Jouanguy, Aurélie Cobat
Özet
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Makale Bilgileri
Dergi
Science
ISSN
0036-8075
Yıl
2020
/ 10. ay
Cilt / Sayı
370
/ 6515
Sayfalar
4585 – 4585
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q1
Yayın Dili
İngilizce
Kapsam
Uluslararası
Toplam Yazar
745 kişi
Erişim Türü
Basılı+Elektronik
Erişim Linki
Makaleye Git
Alan
Sağlık Bilimleri Temel Alanı
Çocuk Enfeksiyon Hastalıkları
YÖKSİS Yazar Kaydı
Yazar Adı
METİN AKCAN ÖZGE, ALKAN GÜLSÜM, ARSLAN ŞEVKET, ÇÖLKESEN FATİH, ÇÖLKESEN FATMA, EMİROĞLU MELİKE, ERDENİZ EMİNE HAFİZE, EROL AYTEKİN SELMA, EVCEN RECEP, GÜL YAHYA, GÜNER ŞÜKRÜ NAİL, ORBAK ZERRİN, GÖK FUNDA, HATİPOĞLU NEVİN, KANAT FİKRET, KAPAKLI HASAN, KARA İSKENDER, KARBUZ ADEM, KART YAŞAR KADRİYE, KELEŞ SEVGİ, KENDİR DEMİRKOL YASEMİN, ÖZÇELİK HASAN TAYFUN, REİSLİ İSMAİL, ŞENOĞLU SEVTAP, VATANSEV HÜLYA, YOSUNKAYA ALPER
YÖKSİS ID
7070889
Hızlı Erişim
Metrikler
Scopus Atıf
1963
JCR Quartile
Q1
Yazar Sayısı
745