Due to trauma, dental anomalies, caries, etc., the teeth may lose vitality before they can complete their root formation. Endodontic treatments in open apex teeth present some difficulties. The fragility of the root walls and the open apex are among the reasons that complicate the endodontic treatment. Regenerative endodontic treatment is a biological-based endodontic treatment option that can provide relief of symptoms, continuation of root development, and vitality of teeth in necrotic, open apex teeth. In regenerative endodontic treatment, after the root canals are disinfected, a biological scaffold is formed within the canal. This scaffold acts as a support to form a regenerative pulp tissue with the help of growth factors and stem cells. Although it is aimed to create organized pulp tissue, true pulp tissue formation has not been proven in the studies. Today, this treatment is recommended as the first choice in the endodontic treatment of immature necrotic teeth. Many studies have shown that this treatment has high success rates on dental survival. In this article, regenerative endodontic treatment and its positive and negative results in the current literature are reviewed.