Objective: The study aimed to determine the levels of anxiety and resilience of nurses working during the COVID-19 pandemic. Materials and Methods: This study was descriptive and cross-sectional design. The study sample consisted of 401 nurses. Study data was collected by researchers through an online survey form. A personal information form, the Beck Anxiety Inventory, and the Brief Resilience Scale were used to collect data. Results: The anxiety mean scores were 19.08±13.23 and the resilience mean scores were 8.87±4.46 for the nurses. It was determined that the nurses being female, lack of protective equipment for COVID-19, caring for COVID-19 patients and low psychological resilience were the factors that predicted the level of anxiety (p<0.05). Conclusions: The study proves that the levels of anxiety and resilience in nurses working during the pandemic are negatively affected.