Objective: This study aims to analyze the effect of the hemodialysis practice on the patients’ sexual functions and sexual experiences. Materials and Methods: Designed as phenomenological research, the study was performed with 19 patients who had hemodialysis treatment from 20 January 2021 to 20 February 2021 and agreed to participate in the study. The research data were collected by using individual in-depth interviews, the researchers’ notes, and patients’ personal notes. The ‘Patient Information Form’ and the semi-structured ‘Interview Form’ were used as the data collection tools. The research data were examined thematically by using the content analysis method. Two main and eight sub-themes were determined. Results: The hemodialysis patients included in the study said that sexuality is an indispensable part of their life, they cannot enjoy sexual intercourse due to hemodialysis, they have fear of damaging the fistula or catheter during sexual intercourse, the frequency of sexual intercourse decreases and/or their sexual life ends, they experience erectile dysfunction due to additional diseases, It was determined that they ‘refused to have sexual intercourse due to fatigue due to hemodialysis and experienced problems in their family relations’, ‘do not want to have intercourse due to religious obligations that must be fulfilled after sexual intercourse, and ‘avoid sexual intercourse due to contamination during the COVID-19 pandemic. Conclusion: In our study, it was found that the sexual functions of the patients who had chronic renal failure and underwent hemodialysis deteriorated. So that the patients will develop positive coping mechanisms against the burden imposed on them by hemodialysis, it is recommended that these patients be oriented toward receiving professional psychological support and be educated about sexuality.