This study researches the impact of trade openness on the economic performances of selected Middle East and North Africa (MENA) countries, while incorporating elements of domestic investments into the empirical analysis in the wake of the recent trends of trade liberalization among nations. The study is based on an empirical analysis of panel data observations from the selected countries within the framework of the Fully Modified Ordinary Least Square (FMOLS) and the Dynamic Ordinary Least Square (DOLS) regression techniques. The empirical results affirm the existence of a long-run relationship among the variables. However, while domestic investment and the size of the labor force significantly impact economic growth in a positive direction among these countries, trade openness was found to be negatively impacting economic growth for the period of the study. It is therefore recommended that cogent effort should be directed towards investments that are crucial for the improvement of labor productivity and the production value chains in the domestic economies to dissuade or minimize the rate of export of raw primary commodities. Also, adequate steps should be taken to improve the overall business environment, remove trade impediments, and strengthen institutions among the countries in the region to harness the benefits of trade in our increasingly globalized world.