Here we describe Centaurea hekimhanensis, a new species found in Hekimhan (Turkey, Malatya Province). This Centaurea grows on the stony-gravel mountain slopes of Yamadağ and is morphologically similar to C. reuteriana, C. bourgaei, and C. pichleri in terms of their flowering lateral stem at the base of the rosette, but differs regarding the shape of the stem and rosette leaves, and the size of the rosette leaves and median appendages; the achene ornamentation is irregularly sulcate. The chromosome number of the new species is 2n = 20.