Scopus Eşleşmesi Bulundu
17
Atıf
14
Cilt
521-526
Sayfa
🔓
Açık Erişim
Scopus Yazarları: Umit Gorkem, Yasin Simsek, Ramazan Kocabaş, Serdar Guler, Ferit Kerim Kucukler
Özet
Introduction: Thyroid dysfunction is among the most common autoimmune disorders in women of reproductive age. Previous studies have shown the association between autoimmune thyroid disease (AITD) and infertility. Anti-Müllerian hormone (AMH) is secreted by granulosa cells and is a useful marker for assessment of ovarian reserve. In the present study, we sought to evaluate the ovarian reserves of women with autoimmune thyroid disorder by measurement of AMH values. Material and methods: This prospective study included women with newly diagnosed AITD aged between 20 and 40 years. Patients were divided into three groups: Subclinical hypothyroidism (SCH, n = 21), overt hypothyroidism (OH, n = 21) and controls (CG, n = 32). Study parameters included serum free T4, free T3, thyroid-stimulating hormone, anti-thyroglobulin, anti-thyroid peroxidase antibodies, follicle-stimulating hormone, luteinizing hormone, estradiol and AMH concentrations measured in the early follicular phase. Antral follicle count (AFC) was assessed with ultrasound. Body mass index (BMI) and waist circumference of the patients were noted. Results: No significant difference was found among SCH, OH and CG in regard to ovarian reserves measured by AMH values (p = 0.19) and AFC (p = 0.80). A significant negative correlation was found between AMH and BMI (r = -0.382, p = 0.001). Anti-Müllerian hormone and waist circumference (r = -0.330, p = 0.004) were also negatively correlated. Conclusions: Although AMH values were not significantly different among groups, AMH values were lower in OH and SCH patients, indicating a possible need for close monitoring of these patients.
Anahtar Kelimeler (Scopus)
Anti-Müllerian hormone
Autoimmune thyroid disease
Fertile women
Anahtar Kelimeler
Anti-Müllerian hormone
Autoimmune thyroid disease
Fertile women
Makale Bilgileri
Dergi
Archives of Medical Science
ISSN
1734-1922
Yıl
2018
/ 1. ay
Cilt / Sayı
14
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q2
TEŞV Puanı
144,00
Yayın Dili
Türkçe
Kapsam
Uluslararası
Toplam Yazar
5 kişi
Erişim Türü
Elektronik
Erişim Linki
Makaleye Git
Alan
Sağlık Bilimleri Temel Alanı
TIP
YÖKSİS Yazar Kaydı
Yazar Adı
KÜÇÜKLER FERİT KERİM, GÖRKEM ÜMİT, ŞİMŞEK YASİN, KOCABAŞ RAMAZAN, GÜLER SERDAR
YÖKSİS ID
5289008
Hızlı Erişim
Metrikler
Scopus Atıf
17
JCR Quartile
Q2
TEŞV Puanı
144,00
Yazar Sayısı
5