Objectives: This study aims to compare the perceived social support and quality of life in individuals with mental health disorders living in nursing home and with family. Methods: This study used relational screening model. The sample consisted of a total of 220 individuals with mental health disorders, including 110 living in eight private nursing homes in Konya, Adana, Antalya, and Yalova and 110 living with their families. Data were collected between October 2015 and April 2017 by using the Interview Form, Multidimensional Scale of Perceived Social Support (MSPSS), Quality of Life Index (QLI) (Wisconsin). Results: There was no significant difference between the QLI mean scores of mentally impaired patients living in nursing home and with family. However, those living with family had significantly higher mean scores on the QLI subscales of living situation and family relations, whereas those living in nursing home had significantly higher mean scores on the QLI subscales of social life and health. In addition, participants living in nursing home had significantly higher mean scores on the MSPSS subscales of significant person and friends, whereas those living with family had significantly higher mean scores on the MSPSS family subscale. There was a significant positive correlation between the groups’ social support and quality of life scale mean scores. Conclusion: Participants living with family had better family relationships and living conditions and more social support from the family, but fewer social circles. Those living in nursing homes had a better social life, more social support from friends and service providers, but fewer family relationships. The results of this study are considered important in terms of providing foresights to service providers, policy makers and researchers.