Scopus Eşleşmesi Bulundu
4
Atıf
19
Cilt
Scopus Yazarları: Ahmet Toprak, Esma Eryilmaz Dogan
Özet
MicroRNAs (miRNA) are a type of non-coding RNA molecules that are effective on the formation and the progression of many different diseases. Various researches have reported that miRNAs play a major role in the prevention, diagnosis, and treatment of complex human diseases. In recent years, researchers have made a tremendous effort to find the potential relationships between miRNAs and diseases. Since the experimental techniques used to find that new miRNA-disease relationships are time-consuming and expensive, many computational techniques have been developed. In this study, Weighted K-Nearest Known Neighbors and Network Consistency Projection techniques were suggested to predict new miRNA-disease relationships using various types of knowledge such as known miRNA-disease relationships, functional similarity of miRNA, and disease semantic similarity. An average AUC of 0.9037 and 0.9168 were calculated in our method by 5-fold and leave-one-out cross validation, respectively. Case studies of breast, lung, and colon neoplasms were applied to prove the performance of our proposed technique, and the results confirmed the predictive reliability of this method. Therefore, reported experimental results have shown that our proposed method can be used as a reliable computational model to reveal potential relationships between miRNAs and diseases.
Anahtar Kelimeler (Scopus)
disease
MiRNA
miRNA-disease association
network consistency projection
similarity measure
weighted K-nearest known neighbors
Anahtar Kelimeler
disease
MiRNA
miRNA-disease association
network consistency projection
similarity measure
weighted K-nearest known neighbors
Makale Bilgileri
Dergi
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
ISSN
0219-7200
Yıl
2021
/ 1. ay
Cilt / Sayı
19
/ 1
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q4
TEŞV Puanı
36,00
Yayın Dili
İngilizce
Kapsam
Uluslararası
Toplam Yazar
2 kişi
Erişim Türü
Elektronik
Erişim Linki
Makaleye Git
Alan
Mühendislik Temel Alanı-
Biyomedikal Mühendisliği
YÖKSİS Yazar Kaydı
Yazar Adı
TOPRAK AHMET,ERYILMAZ ESMA
YÖKSİS ID
4978323
Hızlı Erişim
Metrikler
Scopus Atıf
4
JCR Quartile
Q4
TEŞV Puanı
36,00
Yazar Sayısı
2