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SCI-Expanded JCR Q4 Özgün Makale Scopus
Prediction of miRNA-disease associations based on Weighted K-Nearest known neighbors and network consistency projection
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY 2021 Cilt 19 Sayı 1
Scopus Eşleşmesi Bulundu
4
Atıf
19
Cilt
Scopus Yazarları: Ahmet Toprak, Esma Eryilmaz Dogan
Özet
MicroRNAs (miRNA) are a type of non-coding RNA molecules that are effective on the formation and the progression of many different diseases. Various researches have reported that miRNAs play a major role in the prevention, diagnosis, and treatment of complex human diseases. In recent years, researchers have made a tremendous effort to find the potential relationships between miRNAs and diseases. Since the experimental techniques used to find that new miRNA-disease relationships are time-consuming and expensive, many computational techniques have been developed. In this study, Weighted K-Nearest Known Neighbors and Network Consistency Projection techniques were suggested to predict new miRNA-disease relationships using various types of knowledge such as known miRNA-disease relationships, functional similarity of miRNA, and disease semantic similarity. An average AUC of 0.9037 and 0.9168 were calculated in our method by 5-fold and leave-one-out cross validation, respectively. Case studies of breast, lung, and colon neoplasms were applied to prove the performance of our proposed technique, and the results confirmed the predictive reliability of this method. Therefore, reported experimental results have shown that our proposed method can be used as a reliable computational model to reveal potential relationships between miRNAs and diseases.
Anahtar Kelimeler (Scopus)
disease MiRNA miRNA-disease association network consistency projection similarity measure weighted K-nearest known neighbors

Anahtar Kelimeler

disease MiRNA miRNA-disease association network consistency projection similarity measure weighted K-nearest known neighbors

Makale Bilgileri

Dergi JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
ISSN 0219-7200
Yıl 2021 / 1. ay
Cilt / Sayı 19 / 1
Makale Türü Özgün Makale
Hakemlik Hakemli
Endeks SCI-Expanded
JCR Quartile Q4
TEŞV Puanı 36,00
Yayın Dili İngilizce
Kapsam Uluslararası
Toplam Yazar 2 kişi
Erişim Türü Elektronik
Erişim Linki Makaleye Git
Alan Mühendislik Temel Alanı- Biyomedikal Mühendisliği

YÖKSİS Yazar Kaydı

Yazar Adı TOPRAK AHMET,ERYILMAZ ESMA
YÖKSİS ID 4978323

Metrikler

Scopus Atıf 4
JCR Quartile Q4
TEŞV Puanı 36,00
Yazar Sayısı 2