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SCI-Expanded Kısa Makale Scopus
The impact of early versus late platelet and neutrophil recovery after induction chemotherapy on survival outcomes of patients with acute myeloid leukemia
Turkish Journal of Hematology 2019 Cilt 37 Sayı 2
Scopus Eşleşmesi Bulundu
9
Atıf
37
Cilt
116-120
Sayfa
🔓
Açık Erişim
Scopus Yazarları: Rafiye Çiftçiler, Nilgün Sayınalp, Salih Aksu, Hakan Göker, Ümit Yavuz Malkan, İbrahim Celalettin Haznedaroğlu, Osman Özcebe, Haluk Demiroğlu, Yahya Büyükaşık
Özet
Objective: The prognosis of patients with acute myeloid leukemia (AML) is affected by factors that are both patient-and diseasespecific. The aim of this study is to evaluate the impact of early versus late platelet and neutrophil recovery after induction chemotherapy on survival outcomes of AML patients. Materials and Methods: A total of 181 patients with AML who were treated in our tertiary center between 2001 and 2018 were evaluated. Neutrophil and platelet recovery times were accepted as the periods from the beginning of induction chemotherapy to a neutrophil count of ≥0.5x10<sup>9</sup>/L and a platelet count of ≥20x10<sup>9</sup>/L 3 days in a row, respectively. The median time to platelet recovery was 25 days (range=12-52) for all patients. Therefore, platelet recovery in the first 25 days was defined as early platelet recovery (EPR) and at ≥26 days it was defined as late platelet recovery (LPR). The median time to neutrophil recovery was 28 days (range=13-51) for all patients. Therefore, neutrophil recovery in the first 28 days was defined as early neutrophil recovery, and at ≥29 days it was defined as late neutrophil recovery. Results: The 5-year overall survival (OS) rates for patients who had EPR and LPR after induction chemotherapy were 62% and 23%, respectively (p<0.001). The 5-year disease-free survival (DFS) rates for patients who had EPR and LPR after induction chemotherapy were 57% and 15%, respectively (p<0.001). Conclusion: Short bone marrow recovery time may indicate better healthy hematopoiesis and marrow capacity associated with longer OS and DFS.
Anahtar Kelimeler (Scopus)
Acute myeloid leukemia Neutrophil recovery Platelet recovery
Scimago Dergi Bilgisi Otomatik ISSN Eşleştirmesi 2019 yılı verileri
Turkish Journal of Haematology
Q3
SJR Quartile
0,312
SJR Skoru
25
H-Index
🔓
Açık Erişim
Kategoriler: Hematology (Q3)
Alanlar: Medicine
Ülke: Turkey · AVES
Bu bilgiler makale yılına göre Scimago veritabanından ISSN eşleştirmesiyle otomatik getirilmektedir. Dergi sıralama verileri Scimago'nun ilgili yılı baz alınmaktadır.

Anahtar Kelimeler

Acute myeloid leukemia platelet recovery neutrophil recovery

Makale Bilgileri

Dergi Turkish Journal of Hematology
ISSN 1300-7777
Yıl 2019 / 9. ay
Cilt / Sayı 37 / 2
Sayfalar 116 – 120
Makale Türü Kısa Makale
Hakemlik Hakemli
Endeks SCI-Expanded
Yayın Dili İngilizce
Kapsam Uluslararası
Toplam Yazar 9 kişi
Erişim Türü Basılı+Elektronik
Erişim Linki Makaleye Git
Alan Sağlık Bilimleri Temel Alanı- Hematoloji

YÖKSİS Yazar Kaydı

Yazar Adı ÇİFTÇİLER RAFİYE,HAZNEDAROĞLU İBRAHİM CELALETTİN,SAYINALP NİLGÜN,ÖZCEBE OSMAN İLHAMİ,AKSU SALİH,DEMİROĞLU HALUK,GÖKER HAKAN,MALKAN ÜMİT YAVUZ,BÜYÜKAŞIK YAHYA
YÖKSİS ID 4543948