In the present study, the effects of cefquinome, a 4 generation cephalosporin, on clinical, biochemical, haemato-logical, and blood gas variables were investigated. Five healthy dogs were injected with cefquinome (1 mg/kg body weight, IM, daily) for 14 days. Negative effects of cefquinome on clinical, biochemical, and haematological variables were not observed, but it did change some blood gas variables. © 2001 Taylor & Francis Group, LLC.