This study was carried out on 20 of 8-10 months old Anatolian black goats which were healthy or Linognathus africanus infested (n=10 each). Each goat was housed individually all along the study. Five of ten louse-infested goats were administered vitamin B complex (Benefor enj) intramuscularly at a dose of 40mL/goat.Remaining goats (n=5) were not given vitamin B complex. The other goats that have not been infested with L. africanus were grouped exactly the same as above. All the animals (n=20) were first sensitized and then measured for hypersensitivity reaction in terms of cellular immune response. Infested goats given vitamin B complex were shown a decrease in L. africanus infestation. The other 5 number of infested goats that not given vitamin B complex were detected with an increase in the louse infestation. At the end of the trial, the higher live weight was recorded in healthy goats than those not administered vitamin B complex.