In this paper, we have developed a new method called Generalized Taylor collocation method (GTCM), which is based on the Taylor collocation method, to give approximate solution of linear fractional differential equations with variable coefficients. Using the collocation points, this method transforms fractional differential equation to a matrix equation which corresponds to a system of linear algebraic equations with unknown Generalized Taylor coefficients. Generally, the method is based on computing the Generalized Taylor coefficients by means of the collocation points. This method does not require any intensive computation. Moreover, It is easy to write computer codes in any symbolic language. Hence, the proposed method can be used as effective alternative method for obtaining analytic and approximate solutions for fractional differential equations. The effectiveness of the proposed method is illustrated with some examples. The results show that the method is very effective and convenient in predicting the solutions of such problems. © Association for Scientific Research.