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SSCI Özgün Makale Scopus
The Impact of Body Mass Index on Radiotherapy Technique in Patients With Early Stage Endometrial Cancer
International Journal of Gynecological Cancer 2014 Cilt 24 Sayı 9
Scopus Eşleşmesi Bulundu
7
Atıf
24
Cilt
1607-1615
Sayfa
Scopus Yazarları: Güler Yavaş, Çaǧdaş Yavaş, Özlem Seçilmiş Kerimoğlu, Çetin Çelik
Özet
Objective: We aimed to evaluate the impact of body mass index on radiotherapy (RT) technique in patients with early-stage endometrial cancer. Materials and Methods: Twenty-seven consecutive patients were included in the study and divided into 3 groups with respect to their body mass index (normal weight, 18.5-24.9 kg/m2; overweight, 25-29.9 kg/m2; obese, 30-39.9 kg/m2). Treatment plans using field-in-field (FIF) and 3-dimesional conformal RT (3D-CRT) were compared for the doses in the planning target volume (PTV), organs-at-risk (OAR) volumes, dose homogeneity index, and monitor unit counts required for the treatment. Results: The FIF technique was superior to 3D-CRT with respect to the maximum and mean doses received by OAR and dose homogeneity index values. The subgroup analyses revealed that the maximum dose received by the right femur and the mean doses received by the rectum and bladder were significantly reduced only in obese patients (Ps = 0.021, 0.008, and 0.008, respectively). The FIF technique significantly reduced the PTV volumes irradiated with greater than 105% of the prescribed dose (P < 0.001). The volumes of bowel and bone marrow receiving more than the prescribed dose of 30 Gy were significantly reduced only in obese patients (Ps = 0.025 and 0.043, respectively). The volumes of bladder, bowel, and bone marrow receiving more than the prescribed dose of 45 Gy were significantly reduced in only obese patients (Ps = 0.011, 0.011, and 0.008, respectively). Conclusions: Considering the lower maximum doses in OAR and PTV, we demonstrate the FIF technique to be more advantageous than 3D-CRT during adjuvant RT for early-stage endometrial cancer patients. This advantage is more prominent in obese patients. Therefore, FIF technique represents an effective pelvic RT treatment option for obese patients in clinics that do not have access to or prefer an alternative to intensity-modulated RT.
Anahtar Kelimeler (Scopus)
Body mass index Dose-volume histograms Endometrial cancer Obesity Radiotherapy

Anahtar Kelimeler

Body mass index Dose-volume histograms Endometrial cancer Obesity Radiotherapy

Makale Bilgileri

Dergi International Journal of Gynecological Cancer
ISSN 1048-891X
Yıl 2014 / 1. ay
Cilt / Sayı 24 / 9
Sayfalar 1607 – 1615
Makale Türü Özgün Makale
Hakemlik Hakemli
Endeks SSCI
YÖKSİS Atıf 2
Yayın Dili İngilizce
Kapsam Uluslararası
Toplam Yazar 4 kişi
Erişim Türü Elektronik
Erişim Linki Makaleye Git
Alan Sağlık Bilimleri Temel Alanı- Kadın Hastalıkları ve Doğum

YÖKSİS Yazar Kaydı

Yazar Adı Yavas Guler, Yavas Cagdas, Secilmis Kerimoglu Ozlem, Celik Cetin

Metrikler

YÖKSİS Atıf 2
Scopus Atıf 7
Yazar Sayısı 4